Quick answers
What is Epithalon and what is it used for in research?
How does Epithalon work?
What is the typical Epithalon research dose?
Where can I buy Epithalon in Thailand?
How fast can Epithalon be delivered in Thailand?
What is Epithalon?
Epithalon is a research peptide in the Longevity & Cellular class. Tetrapeptide; studied for telomerase upregulation and pineal function. It is studied at per-dose ranges of 5–10 mg / day (35–70 mg weekly), administered daily sc over cycles of 10–20 day pulse, 2×/year. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.
Synthetic tetrapeptide (Ala-Glu-Asp-Gly). Soviet-era research on telomerase activity and nocturnal melatonin patterns.
Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.
How does Epithalon work?
Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modelled on the natural pineal extract epithalamin. Preclinical work describes upregulation of telomerase (hTERT) activity in somatic cells, restoration of nocturnal melatonin patterns, and effects on chromatin accessibility in aged cells. Human clinical data are limited and concentrated in Soviet-era and Russian literature.
Receptor binding affinity and post-receptor signalling for Epithalon remain areas of active investigation; several proposed effects within the Longevity & Cellular class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.
Epithalon pharmacokinetics
- Half-life
- Short systemic half-life for this tetrapeptide; exact human PK parameters limited in the literature.
- Bioavailability
- SC route is standard in Khavinson-group protocols; intranasal formulations also described.
- Route of administration
- Subcutaneous daily dosing in 10–20 day courses, typically 1–2× yearly.
- Metabolic clearance
- Rapid proteolytic clearance of the Ala-Glu-Asp-Gly sequence.
Epithalon research timeline
- 2003 Khavinson et al., epitalon activates chromatin at old age (Neuro Endocrinol Lett).
- 2003 Anisimov et al., effect on biomarkers of aging, life span, and tumour incidence in mice (Biogerontology).
Epithalon dosage & protocol
Reference protocol for Epithalon (research context only, drawn from published literature):
- Per dose: 5–10 mg / day
- Weekly total: 35–70 mg
- Frequency: Daily SC
- Cycle: 10–20 day pulse, 2×/year
Epithalon injection & handling
- Reconstitution
- Typical research prep: 10 mg vial + 2–3 mL bacteriostatic water.
- Storage
- Lyophilised powder at −20 °C; reconstituted solution refrigerated and used within the 10–20 day course.
- Sites used in the research literature
- Subcutaneous abdomen in daily courses.
Handling notes reflect methods used in published research protocols, not medical dosing guidance.
Stacking Epithalon
Commonly referenced pairing with Epithalon: Monotherapy. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a Epithalon stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.
Contraindications
Limited human data. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.
Further reading
- Fundamentals · 9 min read Understanding Peptide Reconstitution: A Research Guide Practical guide to reconstituting lyophilized research peptides. Choosing a diluent, concentration math, injection-site-ready volumes, and the literature…
- Fundamentals · 10 min read Injection Site Selection in Peptide Research How injection site choice affects peptide absorption: abdomen, thigh, upper arm, and the research literature on site-driven pharmacokinetic differences…
- Buyer guide · 9 min read Best Peptides for Anti-Aging: A Research Comparison Research comparison of Epithalon, MOTS-c, GHK-Cu, Thymosin-α1, and NAD+ for longevity and cellular-aging research. Bangkok research-grade.
- Deep dive · 10 min read Epithalon and Telomerase: Research Background Deep-dive into Epithalon pharmacology. Khavinson-group origin, telomerase activation hypothesis, pineal-melatonin effects, chromatin reactivation, and…
Citations
- Khavinson VK, et al. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003. PMID: 14647006
- Anisimov VN, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003. PMID: 14501183
References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.