Quick answers

What is MOTS-c and what is it used for in research?
MOTS-c is classified within the Longevity & Cellular group. 16-aa mitochondrial-encoded peptide. Activates AMPK; preclinical data in insulin sensitivity and exercise capacity. Research applications focus on the pathways outlined below. All references on this page describe published research only, MOTS-c is supplied for in-vitro and laboratory use, not for human consumption.
How does MOTS-c work?
Primary mechanism: Mitochondrial-derived peptide; activates AMPK, improves metabolic flexibility. Downstream effects depend on dose, timing, and the biological system under investigation. Receptor binding and post-receptor signalling for MOTS-c remain areas of active study, and several proposed effects are supported only by preclinical data.
What is the typical MOTS-c research dose?
Published research protocols for MOTS-c describe per-dose ranges of 5–10 mg × 3 / week, with a weekly total near 15–30 mg, administered 3× weekly sc. Typical cycle: 8–12 weeks. These ranges reflect the literature and are not dosing recommendations for any individual.
Where can I buy MOTS-c in Thailand?
MOTS-c is supplied by Thailand Peptides, a Bangkok-based research-peptide supplier. Orders are placed directly via WhatsApp to the Bangkok research desk, no cart, no account, no forms. Pricing and shipping are provided on request. Open a line with the research desk →
How fast can MOTS-c be delivered in Thailand?
Same-week delivery across Thailand is standard for orders confirmed within business hours (GMT+7, Monday–Saturday). Bangkok metro deliveries typically arrive within 1–3 business days; other provinces within 3–5. Regional Southeast Asia shipping is available on request.

What is MOTS-c?

MOTS-c is a research peptide in the Longevity & Cellular class. Mitochondrial-derived peptide; activates AMPK, improves metabolic flexibility. It is studied at per-dose ranges of 5–10 mg × 3 / week (15–30 mg weekly), administered 3× weekly sc over cycles of 8–12 weeks. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.

16-aa mitochondrial-encoded peptide. Activates AMPK; preclinical data in insulin sensitivity and exercise capacity.

Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.

How does MOTS-c work?

MOTS-c is encoded within the mitochondrial 12S rRNA gene and acts as a signalling peptide between mitochondria and the nucleus. It activates AMP-activated protein kinase (AMPK) via modulation of the folate–methionine cycle, improves insulin sensitivity, and translocates to the nucleus under metabolic stress where it interacts with stress-response transcription factors. Exercise acutely elevates circulating MOTS-c in animal and human studies.

Receptor binding affinity and post-receptor signalling for MOTS-c remain areas of active investigation; several proposed effects within the Longevity & Cellular class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.

MOTS-c pharmacokinetics

Half-life
Short systemic half-life for this 16-amino-acid mitochondrial-derived peptide.
Bioavailability
SC bioavailability used in preclinical protocols; endogenous MOTS-c is exercise-induced.
Route of administration
Subcutaneous injection 2–3 times weekly in research protocols.
Metabolic clearance
Proteolytic; detailed human PK remains under investigation.

MOTS-c research timeline

  1. 2015 Lee et al., MOTS-c promotes metabolic homeostasis via AMPK (Cell Metab).
  2. 2021 Reynolds et al., MOTS-c as exercise-induced regulator of age-dependent physical decline (Nat Commun).

MOTS-c dosage & protocol

Reference protocol for MOTS-c (research context only, drawn from published literature):

  • Per dose: 5–10 mg × 3 / week
  • Weekly total: 15–30 mg
  • Frequency: 3× weekly SC
  • Cycle: 8–12 weeks

MOTS-c injection & handling

Reconstitution
Typical research prep: 10 mg vial + 2–3 mL bacteriostatic water, yielding 3.3–5 mg/mL.
Storage
Lyophilised powder at −20 °C; reconstituted solution refrigerated and used within research-protocol timeframes.
Sites used in the research literature
Subcutaneous abdomen; 3× weekly dosing benefits from site rotation.

Handling notes reflect methods used in published research protocols, not medical dosing guidance.

Order MOTS-c
Ready to order? WhatsApp the Bangkok research desk, pricing and availability confirmed within the chat.
Ask about MOTS-c ≥98% HPLC purity · supplier COA on file · Bangkok-based

Stacking MOTS-c

Commonly referenced pairing with MOTS-c: Monotherapy. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a MOTS-c stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.

Contraindications

Unestablished long-term data. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.

Research summaries

Further reading

Compare MOTS-c with: Epithalon GHK-Cu

Citations

  1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. PMID: 25738459
  2. Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021. PMID: 33473109

References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.