Quick answers
What is CJC-1295 and what is it used for in research?
How does CJC-1295 work?
What is the typical CJC-1295 research dose?
Where can I buy CJC-1295 in Thailand?
How fast can CJC-1295 be delivered in Thailand?
What is CJC-1295?
CJC-1295 is a research peptide in the GH Secretagogue class. GHRH analog (No DAC, daily dosing). It is studied at per-dose ranges of 100 mcg × 2–3 / day (1.4–2.1 mg weekly), administered daily sc over cycles of 12 weeks on / 4 off. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.
Modified GHRH(1-29) without DAC, short half-life. Daily SC dosing. The DAC variant is a separate SKU.
Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.
How does CJC-1295 work?
CJC-1295 is a modified GHRH(1-29) analogue. The DAC (Drug Affinity Complex) variant carries a maleimidopropionic acid linker that forms a covalent bond with circulating albumin, dramatically extending half-life and producing sustained elevation of baseline GH and IGF-1. Like native GHRH, it acts on the GHRH receptor on somatotrophs, but its pharmacology is closer to continuous stimulation than pulsatile release.
Receptor binding affinity and post-receptor signalling for CJC-1295 remain areas of active investigation; several proposed effects within the GH Secretagogue class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.
CJC-1295 pharmacokinetics
- Half-life
- DAC-modified variant: approximately 8 days due to covalent albumin binding. Non-DAC (mod-GRF 1-29): ~30 minutes.
- Bioavailability
- SC bioavailability described as high in Phase 1 trials of the DAC variant.
- Route of administration
- Subcutaneous injection 1–2× weekly for the DAC form; the non-DAC form is dosed multiple times daily.
- Metabolic clearance
- Proteolytic degradation while bound to albumin; cleared gradually as albumin turns over.
CJC-1295 research timeline
- 2006 Teichman et al., prolonged GH and IGF-1 elevation with weekly SC CJC-1295 (J Clin Endocrinol Metab).
CJC-1295 dosage & protocol
Reference protocol for CJC-1295 (research context only, drawn from published literature):
- Per dose: 100 mcg × 2–3 / day
- Weekly total: 1.4–2.1 mg
- Frequency: Daily SC
- Cycle: 12 weeks on / 4 off
CJC-1295 injection & handling
- Reconstitution
- Typical research prep: 2 mg vial + 2 mL bacteriostatic water, yielding 1 mg/mL.
- Storage
- Lyophilised powder at −20 °C; reconstituted solution refrigerated and stable for 2–4 weeks in research protocols.
- Sites used in the research literature
- Subcutaneous abdomen; weekly dosing simplifies site rotation.
Handling notes reflect methods used in published research protocols, not medical dosing guidance.
Stacking CJC-1295
Commonly referenced pairing with CJC-1295: Ipamorelin. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a CJC-1295 stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.
Contraindications
Active malignancy, pregnancy. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.
Further reading
- Fundamentals · 9 min read Understanding Peptide Reconstitution: A Research Guide Practical guide to reconstituting lyophilized research peptides. Choosing a diluent, concentration math, injection-site-ready volumes, and the literature…
- Fundamentals · 10 min read Injection Site Selection in Peptide Research How injection site choice affects peptide absorption: abdomen, thigh, upper arm, and the research literature on site-driven pharmacokinetic differences…
- Buyer guide · 9 min read Best Peptides for Muscle Growth: A Research Comparison Research comparison of Ipamorelin, CJC-1295, Tesamorelin, and Hexarelin for growth-hormone and lean-mass research.
- Deep dive · 11 min read Ipamorelin and CJC-1295: Mechanistic Differences in GH Release Deep-dive comparison of Ipamorelin and CJC-1295 at the receptor level. GHS-R1a vs GHRH-R pharmacology, selectivity, pulsatile vs sustained signalling…
Citations
- Teichman SL, et al. Prolonged stimulation of growth hormone and insulin-like growth factor I secretion by CJC-1295. J Clin Endocrinol Metab. 2006. PMID: 16352683
- Ionescu M, et al. Pulsatile secretion of growth hormone persists during continuous stimulation by CJC-1295, a long-acting GHRH analog. J Clin Endocrinol Metab. 2006. PMID: 17018654
References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.