Quick answers
What is Hexarelin and what is it used for in research?
How does Hexarelin work?
What is the typical Hexarelin research dose?
Where can I buy Hexarelin in Thailand?
How fast can Hexarelin be delivered in Thailand?
What is Hexarelin?
Hexarelin is a research peptide in the GH Secretagogue class. Potent ghrelin-receptor agonist; strong acute GH release. It is studied at per-dose ranges of 100 mcg × 2–3 / day (2–4 mg weekly), administered 2–3× daily sc over cycles of 4–8 weeks. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.
Hexapeptide GHS. Stronger acute GH-release profile than ipamorelin but with greater cortisol/prolactin impact.
Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.
How does Hexarelin work?
Hexarelin is a synthetic hexapeptide GHS that activates both the ghrelin receptor (GHS-R1a) and CD36. It produces a strong acute GH response, typically higher peak than ipamorelin, but also elevates cortisol, prolactin, and ACTH to a greater degree, and chronic dosing shows GH-response attenuation (tachyphylaxis). This profile is why ipamorelin is usually preferred for sustained research protocols.
Receptor binding affinity and post-receptor signalling for Hexarelin remain areas of active investigation; several proposed effects within the GH Secretagogue class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.
Hexarelin pharmacokinetics
- Half-life
- Approximately 55–70 minutes after SC administration in clinical studies.
- Bioavailability
- Rapid SC absorption; acute GH peak typically within 15–30 minutes.
- Route of administration
- Subcutaneous injection; early studies also used IV and intranasal routes.
- Metabolic clearance
- Rapid proteolytic degradation with predominantly renal excretion of fragments.
Hexarelin research timeline
- 1994 Ghigo et al., early characterisation of hexarelin GH-releasing activity in humans.
- 2003 Broglio et al., cardiovascular actions of GH secretagogues including hexarelin.
Hexarelin dosage & protocol
Reference protocol for Hexarelin (research context only, drawn from published literature):
- Per dose: 100 mcg × 2–3 / day
- Weekly total: 2–4 mg
- Frequency: 2–3× daily SC
- Cycle: 4–8 weeks
Hexarelin injection & handling
- Reconstitution
- Typical research prep: 5 mg vial + 2 mL bacteriostatic water, yielding 2.5 mg/mL.
- Storage
- Lyophilised powder at −20 °C; reconstituted solution refrigerated and used within 2–4 weeks.
- Sites used in the research literature
- Subcutaneous abdomen; frequent dosing benefits from site rotation.
Handling notes reflect methods used in published research protocols, not medical dosing guidance.
Stacking Hexarelin
Commonly referenced pairing with Hexarelin: GHRH analog. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a Hexarelin stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.
Contraindications
Active malignancy. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.
Further reading
- Fundamentals · 9 min read Understanding Peptide Reconstitution: A Research Guide Practical guide to reconstituting lyophilized research peptides. Choosing a diluent, concentration math, injection-site-ready volumes, and the literature…
- Fundamentals · 10 min read Injection Site Selection in Peptide Research How injection site choice affects peptide absorption: abdomen, thigh, upper arm, and the research literature on site-driven pharmacokinetic differences…
- Buyer guide · 9 min read Best Peptides for Muscle Growth: A Research Comparison Research comparison of Ipamorelin, CJC-1295, Tesamorelin, and Hexarelin for growth-hormone and lean-mass research.
- Deep dive · 11 min read Cycle Design for Growth Hormone Secretagogues How to design GHS cycles that preserve response over weeks of research dosing. Tachyphylaxis biology, GHRH analog chronicity, cycle length, break…
Citations
- Ghigo E, et al. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide. J Clin Endocrinol Metab. 1994. PMID: 8126144
- Arvat E, et al. Arginine and growth hormone-releasing hormone restore the blunted GH-releasing activity of hexarelin in elderly subjects. J Clin Endocrinol Metab. 1994. PMID: 7962341
References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.