Quick answers
What is Ipamorelin and what is it used for in research?
How does Ipamorelin work?
What is the typical Ipamorelin research dose?
Where can I buy Ipamorelin in Thailand?
How fast can Ipamorelin be delivered in Thailand?
What is Ipamorelin?
Ipamorelin is a research peptide in the GH Secretagogue class. Selective ghrelin-receptor agonist; GH-specific with minimal cortisol or prolactin effect. It is studied at per-dose ranges of 200–300 mcg × 2–3 / day (4–6 mg weekly), administered 2–3× daily sc over cycles of 12 weeks on / 4 off. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.
Pentapeptide GHS. Acts on GHS-R1a without appreciable effect on cortisol, prolactin, or appetite at standard research doses.
Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.
How does Ipamorelin work?
Ipamorelin is a selective agonist of the growth-hormone secretagogue receptor type 1a (GHS-R1a, the ghrelin receptor). It stimulates GH release with high specificity and, unlike earlier GHS peptides such as hexarelin or GHRP-6, without clinically meaningful elevations of cortisol, prolactin, or ACTH at research doses. This selectivity profile is the primary reason ipamorelin is the GHS of choice in contemporary research protocols.
Receptor binding affinity and post-receptor signalling for Ipamorelin remain areas of active investigation; several proposed effects within the GH Secretagogue class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.
Ipamorelin pharmacokinetics
- Half-life
- Approximately 2 hours after SC administration in healthy subjects.
- Bioavailability
- Rapid SC absorption with GH response peaking within ~30–60 minutes.
- Route of administration
- Subcutaneous injection, typically 2–3 times daily in research protocols to mimic physiological GH pulsatility.
- Metabolic clearance
- Proteolytic degradation; predominantly renal excretion of fragments.
Ipamorelin research timeline
- 1998 Raun et al., ipamorelin characterised as first selective GH secretagogue (Eur J Endocrinol).
- 1999 Gobburu et al., pharmacokinetic-pharmacodynamic modelling of GH response (J Pharmacol Exp Ther).
Ipamorelin dosage & protocol
Reference protocol for Ipamorelin (research context only, drawn from published literature):
- Per dose: 200–300 mcg × 2–3 / day
- Weekly total: 4–6 mg
- Frequency: 2–3× daily SC
- Cycle: 12 weeks on / 4 off
Ipamorelin injection & handling
- Reconstitution
- Typical research prep: 5 mg vial + 2–3 mL bacteriostatic water, yielding ~1.67–2.5 mg/mL.
- Storage
- Lyophilised powder at −20 °C; reconstituted solution refrigerated and used within 4 weeks in published protocols.
- Sites used in the research literature
- Subcutaneous abdomen is the most common site; alternate sides to reduce local irritation.
Handling notes reflect methods used in published research protocols, not medical dosing guidance.
Stacking Ipamorelin
Commonly referenced pairing with Ipamorelin: CJC-1295, Tesamorelin. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a Ipamorelin stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.
Contraindications
Active malignancy. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.
Further reading
- Fundamentals · 9 min read Understanding Peptide Reconstitution: A Research Guide Practical guide to reconstituting lyophilized research peptides. Choosing a diluent, concentration math, injection-site-ready volumes, and the literature…
- Fundamentals · 10 min read Injection Site Selection in Peptide Research How injection site choice affects peptide absorption: abdomen, thigh, upper arm, and the research literature on site-driven pharmacokinetic differences…
- Buyer guide · 9 min read Best Peptides for Muscle Growth: A Research Comparison Research comparison of Ipamorelin, CJC-1295, Tesamorelin, and Hexarelin for growth-hormone and lean-mass research.
- Deep dive · 11 min read Ipamorelin and CJC-1295: Mechanistic Differences in GH Release Deep-dive comparison of Ipamorelin and CJC-1295 at the receptor level. GHS-R1a vs GHRH-R pharmacology, selectivity, pulsatile vs sustained signalling…
Citations
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998. PMID: 9849822
- Gobburu JV, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999. PMID: 10496658
References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.