Quick answers
What is LL-37 and what is it used for in research?
How does LL-37 work?
What is the typical LL-37 research dose?
Where can I buy LL-37 in Thailand?
How fast can LL-37 be delivered in Thailand?
What is LL-37?
LL-37 is a research peptide in the Healing & Recovery class. Cathelicidin-derived antimicrobial peptide; immune modulation. It is studied at per-dose ranges of 100–500 mcg / day (Variable weekly), administered daily sc over cycles of research dependent. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.
Human cathelicidin fragment with antimicrobial and wound-healing activity. Active research area.
Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.
How does LL-37 work?
LL-37 is the sole human cathelicidin-derived antimicrobial peptide, a 37-residue amphipathic α-helical peptide. It disrupts bacterial membranes via electrostatic interaction with anionic lipids and also modulates innate immunity through effects on chemokine release, epithelial wound-healing signalling, and angiogenesis. Active research covers infection, wound healing, and tumour biology.
Receptor binding affinity and post-receptor signalling for LL-37 remain areas of active investigation; several proposed effects within the Healing & Recovery class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.
LL-37 pharmacokinetics
- Half-life
- Short systemic half-life; PK parameters are an active research area and depend on formulation.
- Bioavailability
- SC and topical routes both used in research; IV route reported in septic-shock research.
- Route of administration
- Subcutaneous injection in research protocols; topical formulations in wound-healing work.
- Metabolic clearance
- Rapid proteolytic clearance; some fragments retain partial activity.
LL-37 research timeline
- 2012 Vandamme et al., comprehensive summary of LL-37 as a factotum human cathelicidin peptide (Cell Immunol).
LL-37 dosage & protocol
Reference protocol for LL-37 (research context only, drawn from published literature):
- Per dose: 100–500 mcg / day
- Weekly total: Variable
- Frequency: Daily SC
- Cycle: Research dependent
LL-37 injection & handling
- Reconstitution
- Typical research prep: 5 mg vial + 2 mL bacteriostatic water, yielding 2.5 mg/mL.
- Storage
- Lyophilised powder at −20 °C; reconstituted solution refrigerated and used within 2–4 weeks.
- Sites used in the research literature
- Subcutaneous abdomen in systemic research; topical application to wound bed in local-delivery research.
Handling notes reflect methods used in published research protocols, not medical dosing guidance.
Stacking LL-37
Commonly referenced pairing with LL-37: Monotherapy. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a LL-37 stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.
Contraindications
Autoimmune conditions. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.
Further reading
- Fundamentals · 9 min read Understanding Peptide Reconstitution: A Research Guide Practical guide to reconstituting lyophilized research peptides. Choosing a diluent, concentration math, injection-site-ready volumes, and the literature…
- Fundamentals · 10 min read Injection Site Selection in Peptide Research How injection site choice affects peptide absorption: abdomen, thigh, upper arm, and the research literature on site-driven pharmacokinetic differences…
- Buyer guide · 9 min read Best Peptides for Healing and Recovery: A Research Comparison Research comparison of BPC-157, TB-500, Thymosin-α1, and LL-37 for soft-tissue repair and recovery research.
- Deep dive · 10 min read Healing Peptide Stacking: BPC-157 and TB-500 Research Protocols The BPC-157 + TB-500 stack: mechanism complementarity, protocol design, evidence base, and honest framing of where the literature is strong versus where…
Citations
- Vandamme D, et al. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012. PMID: 23246832
References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.