Quick answers

What is Melanotan-II and what is it used for in research?
Melanotan-II is classified within the Body Recomposition group. Synthetic melanocortin-receptor agonist. Research use only; multiple off-target MC-receptor effects. Research applications focus on the pathways outlined below. All references on this page describe published research only, Melanotan-II is supplied for in-vitro and laboratory use, not for human consumption.
How does Melanotan-II work?
Primary mechanism: Non-selective melanocortin agonist; studied for melanogenesis. Downstream effects depend on dose, timing, and the biological system under investigation. Receptor binding and post-receptor signalling for Melanotan-II remain areas of active study, and several proposed effects are supported only by preclinical data.
What is the typical Melanotan-II research dose?
Published research protocols for Melanotan-II describe per-dose ranges of 250–500 mcg / day (loading), with a weekly total near Variable, administered daily sc during loading. Typical cycle: 2 weeks loading + maintenance. These ranges reflect the literature and are not dosing recommendations for any individual.
Where can I buy Melanotan-II in Thailand?
Melanotan-II is supplied by Thailand Peptides, a Bangkok-based research-peptide supplier. Orders are placed directly via WhatsApp to the Bangkok research desk, no cart, no account, no forms. Pricing and shipping are provided on request. Open a line with the research desk →
How fast can Melanotan-II be delivered in Thailand?
Same-week delivery across Thailand is standard for orders confirmed within business hours (GMT+7, Monday–Saturday). Bangkok metro deliveries typically arrive within 1–3 business days; other provinces within 3–5. Regional Southeast Asia shipping is available on request.

What is Melanotan-II?

Melanotan-II is a research peptide in the Body Recomposition class. Non-selective melanocortin agonist; studied for melanogenesis. It is studied at per-dose ranges of 250–500 mcg / day (loading) (Variable weekly), administered daily sc during loading over cycles of 2 weeks loading + maintenance. Supplied in Thailand by Thailand Peptides, Bangkok-based, research use only.

Synthetic melanocortin-receptor agonist. Research use only; multiple off-target MC-receptor effects.

Published and preclinical data are summarised below; dose ranges shown reflect protocols in the research literature and should be interpreted accordingly.

How does Melanotan-II work?

Melanotan-II is a synthetic cyclic analogue of α-MSH that acts as a non-selective agonist at melanocortin receptors 1 through 5. MC1 activation produces melanogenesis; MC3 and MC4 activation account for the appetite, sexual, and autonomic effects. The non-selective profile is both its utility in MC-receptor research and the source of off-target side-effect risk.

Receptor binding affinity and post-receptor signalling for Melanotan-II remain areas of active investigation; several proposed effects within the Body Recomposition class are currently supported only by in-vitro or rodent data, and should be interpreted accordingly.

Melanotan-II pharmacokinetics

Half-life
Approximately 1–2 hours after SC administration in reported studies.
Bioavailability
Good SC absorption; oral bioavailability negligible due to proteolytic degradation.
Route of administration
Subcutaneous injection daily during a loading phase, then as needed for maintenance.
Metabolic clearance
Proteolytic clearance of the cyclic peptide backbone.

Melanotan-II research timeline

  1. 1990s Dorr and colleagues (University of Arizona) develop the compound for photoprotection research.

Melanotan-II dosage & protocol

Reference protocol for Melanotan-II (research context only, drawn from published literature):

  • Per dose: 250–500 mcg / day (loading)
  • Weekly total: Variable
  • Frequency: Daily SC during loading
  • Cycle: 2 weeks loading + maintenance

Melanotan-II injection & handling

Reconstitution
Typical research prep: 10 mg vial + 5 mL bacteriostatic water, yielding 2 mg/mL.
Storage
Lyophilised powder at −20 °C; reconstituted solution refrigerated and used within research-protocol timeframes.
Sites used in the research literature
Subcutaneous abdomen or thigh; daily loading phase followed by maintenance dosing.

Handling notes reflect methods used in published research protocols, not medical dosing guidance.

Order Melanotan-II
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Stacking Melanotan-II

Commonly referenced pairing with Melanotan-II: Monotherapy. Stacking rationale should be grounded in complementary mechanisms, not additive speculation; interactions at shared receptors or enzymatic pathways should be accounted for. Both compounds in a Melanotan-II stack are supplied by Thailand Peptides on the same order via the Bangkok research desk.

Contraindications

Atypical moles, melanoma history. Additional caution is warranted in individuals with hepatic or renal impairment, endocrine disorders, or concurrent pharmacotherapy affecting the pathways described above.

Further reading

Compare Melanotan-II with: PT-141

Citations

  1. Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996. PMID: 8637402
  2. Wessells H, et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000. PMID: 11035391

References curated from PubMed. Additional literature summarised in the Thailand Peptides research library.